RapamycinFungusV1, Main, Exploration, bibRecord, 000318

Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.

Identifieur interne : 000318 ( Main/Exploration ); précédent : 000317; suivant : 000319

Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.

Source :

Autophagy [ 1554-8635 ] ; 2019.

RBID : pubmed:30741586

Descripteurs français

English descriptors

KwdEn :
- A549 Cells (MeSH), Adaptor Proteins, Signal Transducing (genetics), Adaptor Proteins, Signal Transducing (metabolism), Autophagosomes (immunology), Autophagosomes (metabolism), Autophagosomes (virology), Autophagy (genetics), Autophagy (immunology), Autophagy-Related Protein 5 (genetics), Autophagy-Related Protein 5 (metabolism), Calcium (immunology), Calcium (metabolism), HEK293 Cells (MeSH), HeLa Cells (MeSH), Humans (MeSH), Immunity, Innate (genetics), Influenza A virus (immunology), Influenza A virus (metabolism), Influenza A virus (pathogenicity), Mitochondria (metabolism), Mitochondria (virology), Mitochondrial Dynamics (genetics), Phosphatidylinositol 3-Kinases (genetics), Phosphatidylinositol 3-Kinases (metabolism), Protein Binding (MeSH), Proto-Oncogene Proteins c-akt (genetics), Proto-Oncogene Proteins c-akt (metabolism), Reactive Oxygen Species (metabolism), Signal Transduction (genetics), Signal Transduction (immunology), TOR Serine-Threonine Kinases (genetics), TOR Serine-Threonine Kinases (metabolism), Viral Matrix Proteins (genetics), Viral Matrix Proteins (metabolism).
MESH :
- chemical , genetics : Adaptor Proteins, Signal Transducing, Autophagy-Related Protein 5, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases, Viral Matrix Proteins.
- chemical , immunology : Calcium.
- chemical , metabolism : Adaptor Proteins, Signal Transducing, Autophagy-Related Protein 5, Calcium, Proto-Oncogene Proteins c-akt, Reactive Oxygen Species, TOR Serine-Threonine Kinases, Viral Matrix Proteins.
- genetics : Autophagy, Immunity, Innate, Mitochondrial Dynamics, Phosphatidylinositol 3-Kinases, Signal Transduction.
- immunology : Autophagosomes, Autophagy, Influenza A virus, Signal Transduction.
- metabolism : Autophagosomes, Influenza A virus, Mitochondria, Phosphatidylinositol 3-Kinases.
- pathogenicity : Influenza A virus.
- virology : Autophagosomes, Mitochondria.
- A549 Cells, HEK293 Cells, HeLa Cells, Humans, Protein Binding.

Abstract

Influenza A virus can evade host innate immune response that is involved in several viral proteins with complicated mechanisms. To date, how influenza A M2 protein modulates the host innate immunity remains unclear. Herein, we showed that M2 protein colocalized and interacted with MAVS (mitochondrial antiviral signaling protein) on mitochondria, and positively regulated MAVS-mediated innate immunity. Further studies revealed that M2 induced reactive oxygen species (ROS) production that was required for activation of macroautophagy/autophagy and enhancement of MAVS signaling pathway. Importantly, the proton channel activity of M2 protein was demonstrated to be essential for ROS production and antagonizing the autophagy pathway to control MAVS aggregation, thereby enhancing MAVS signal activity. In conclusion, our studies provided novel insights into mechanisms of M2 protein in modulating host antiviral immunity and uncovered a new mechanism into biology and pathogenicity of influenza A virus. Abbreviations: AKT/PKB: AKT serine/threonine kinase; Apo: apocynin; ATG5: autophagy related 5; BAPTA-AM: 1,2-Bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid tetrakis; BECN1: beclin 1; CARD: caspase recruitment domain; CCCP: carbonyl cyanide m-chlorophenylhydrazone; CQ: chloroquine; DCF: dichlorodihyd-rofluorescein; DPI: diphenyleneiodonium; DDX58: DExD/H-box helicase 58; eGFP: enhanced green fluorescent protein; EGTA: ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid; ER: endoplasmic reticulum; hpi: hours post infection; IAV: influenza A virus; IFN: interferon; IP: immunoprecipitation; IRF3: interferon regulatory factor 3; ISRE: IFN-stimulated response elements; LIR: LC3-interacting region; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAVS: mitochondrial antiviral signaling protein; MMP: mitochondrial membrane potential; MOI, multiplicity of infection; mRFP: monomeric red fluorescent protein; MTOR: mechanistic target of rapamycin kinase; NC: negative control; NFKB/NF-κB: nuclear factor kappa B; PI3K: class I phosphoinositide 3-kinase; RLR: RIG-I-like-receptor; ROS: reactive oxygen species; SEV: sendai virus; TM: transmembrane; TMRM: tetramethylrhodamine methylester; VSV: vesicular stomatitis virus.

DOI: 10.1080/15548627.2019.1580089
PubMed: 30741586
PubMed Central: PMC6613841

Affiliations:

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Le document en format XML

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<author><name sortKey="Ren, Chenwei" sort="Ren, Chenwei" uniqKey="Ren C" first="Chenwei" last="Ren">Chenwei Ren</name>
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<author><name sortKey="Zhao, Jiachang" sort="Zhao, Jiachang" uniqKey="Zhao J" first="Jiachang" last="Zhao">Jiachang Zhao</name>
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<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
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<author><name sortKey="Wang, Fangfang" sort="Wang, Fangfang" uniqKey="Wang F" first="Fangfang" last="Wang">Fangfang Wang</name>
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<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
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<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
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<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
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<author><name sortKey="Zhao, Lianzhong" sort="Zhao, Lianzhong" uniqKey="Zhao L" first="Lianzhong" last="Zhao">Lianzhong Zhao</name>
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<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
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<author><name sortKey="Chen, Huanchun" sort="Chen, Huanchun" uniqKey="Chen H" first="Huanchun" last="Chen">Huanchun Chen</name>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
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<author><name sortKey="Jin, Meilin" sort="Jin, Meilin" uniqKey="Jin M" first="Meilin" last="Jin">Meilin Jin</name>
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<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
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<author><name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>c Department of Diagnostic Medicine and Pathobiology , Kansas State University , Manhattan , KS </wicri:regionArea>
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</placeName>
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<author><name sortKey="Zhou, Hongbo" sort="Zhou, Hongbo" uniqKey="Zhou H" first="Hongbo" last="Zhou">Hongbo Zhou</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.</title>
<author><name sortKey="Wang, Ruifang" sort="Wang, Ruifang" uniqKey="Wang R" first="Ruifang" last="Wang">Ruifang Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhu, Yinxing" sort="Zhu, Yinxing" uniqKey="Zhu Y" first="Yinxing" last="Zhu">Yinxing Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Xian" sort="Lin, Xian" uniqKey="Lin X" first="Xian" last="Lin">Xian Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ren, Chenwei" sort="Ren, Chenwei" uniqKey="Ren C" first="Chenwei" last="Ren">Chenwei Ren</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Jiachang" sort="Zhao, Jiachang" uniqKey="Zhao J" first="Jiachang" last="Zhao">Jiachang Zhao</name>
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<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Fangfang" sort="Wang, Fangfang" uniqKey="Wang F" first="Fangfang" last="Wang">Fangfang Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Xiaochen" sort="Gao, Xiaochen" uniqKey="Gao X" first="Xiaochen" last="Gao">Xiaochen Gao</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiao, Rong" sort="Xiao, Rong" uniqKey="Xiao R" first="Rong" last="Xiao">Rong Xiao</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Lianzhong" sort="Zhao, Lianzhong" uniqKey="Zhao L" first="Lianzhong" last="Zhao">Lianzhong Zhao</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Huanchun" sort="Chen, Huanchun" uniqKey="Chen H" first="Huanchun" last="Chen">Huanchun Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jin, Meilin" sort="Jin, Meilin" uniqKey="Jin M" first="Meilin" last="Jin">Meilin Jin</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name>
<affiliation wicri:level="2"><nlm:affiliation>c Department of Diagnostic Medicine and Pathobiology , Kansas State University , Manhattan , KS , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>c Department of Diagnostic Medicine and Pathobiology , Kansas State University , Manhattan , KS </wicri:regionArea>
<placeName><region type="state">Kansas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Hongbo" sort="Zhou, Hongbo" uniqKey="Zhou H" first="Hongbo" last="Zhou">Hongbo Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan </wicri:regionArea>
<wicri:noRegion>Wuhan </wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Autophagy</title>
<idno type="eISSN">1554-8635</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells (MeSH)</term>
<term>Adaptor Proteins, Signal Transducing (genetics)</term>
<term>Adaptor Proteins, Signal Transducing (metabolism)</term>
<term>Autophagosomes (immunology)</term>
<term>Autophagosomes (metabolism)</term>
<term>Autophagosomes (virology)</term>
<term>Autophagy (genetics)</term>
<term>Autophagy (immunology)</term>
<term>Autophagy-Related Protein 5 (genetics)</term>
<term>Autophagy-Related Protein 5 (metabolism)</term>
<term>Calcium (immunology)</term>
<term>Calcium (metabolism)</term>
<term>HEK293 Cells (MeSH)</term>
<term>HeLa Cells (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunity, Innate (genetics)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (metabolism)</term>
<term>Influenza A virus (pathogenicity)</term>
<term>Mitochondria (metabolism)</term>
<term>Mitochondria (virology)</term>
<term>Mitochondrial Dynamics (genetics)</term>
<term>Phosphatidylinositol 3-Kinases (genetics)</term>
<term>Phosphatidylinositol 3-Kinases (metabolism)</term>
<term>Protein Binding (MeSH)</term>
<term>Proto-Oncogene Proteins c-akt (genetics)</term>
<term>Proto-Oncogene Proteins c-akt (metabolism)</term>
<term>Reactive Oxygen Species (metabolism)</term>
<term>Signal Transduction (genetics)</term>
<term>Signal Transduction (immunology)</term>
<term>TOR Serine-Threonine Kinases (genetics)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>Viral Matrix Proteins (genetics)</term>
<term>Viral Matrix Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Autophagie (génétique)</term>
<term>Autophagie (immunologie)</term>
<term>Autophagosomes (immunologie)</term>
<term>Autophagosomes (métabolisme)</term>
<term>Autophagosomes (virologie)</term>
<term>Calcium (immunologie)</term>
<term>Calcium (métabolisme)</term>
<term>Cellules A549 (MeSH)</term>
<term>Cellules HEK293 (MeSH)</term>
<term>Cellules HeLa (MeSH)</term>
<term>Dynamique mitochondriale (génétique)</term>
<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Immunité innée (génétique)</term>
<term>Liaison aux protéines (MeSH)</term>
<term>Mitochondries (métabolisme)</term>
<term>Mitochondries (virologie)</term>
<term>Phosphatidylinositol 3-kinases (génétique)</term>
<term>Phosphatidylinositol 3-kinases (métabolisme)</term>
<term>Protéine-5 associée à l'autophagie (génétique)</term>
<term>Protéine-5 associée à l'autophagie (métabolisme)</term>
<term>Protéines adaptatrices de la transduction du signal (génétique)</term>
<term>Protéines adaptatrices de la transduction du signal (métabolisme)</term>
<term>Protéines de la matrice virale (génétique)</term>
<term>Protéines de la matrice virale (métabolisme)</term>
<term>Protéines proto-oncogènes c-akt (génétique)</term>
<term>Protéines proto-oncogènes c-akt (métabolisme)</term>
<term>Sérine-thréonine kinases TOR (génétique)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (génétique)</term>
<term>Transduction du signal (immunologie)</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Virus de la grippe A (métabolisme)</term>
<term>Virus de la grippe A (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term>
<term>Autophagy-Related Protein 5</term>
<term>Proto-Oncogene Proteins c-akt</term>
<term>TOR Serine-Threonine Kinases</term>
<term>Viral Matrix Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Calcium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term>
<term>Autophagy-Related Protein 5</term>
<term>Calcium</term>
<term>Proto-Oncogene Proteins c-akt</term>
<term>Reactive Oxygen Species</term>
<term>TOR Serine-Threonine Kinases</term>
<term>Viral Matrix Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Autophagy</term>
<term>Immunity, Innate</term>
<term>Mitochondrial Dynamics</term>
<term>Phosphatidylinositol 3-Kinases</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Autophagie</term>
<term>Dynamique mitochondriale</term>
<term>Immunité innée</term>
<term>Phosphatidylinositol 3-kinases</term>
<term>Protéine-5 associée à l'autophagie</term>
<term>Protéines adaptatrices de la transduction du signal</term>
<term>Protéines de la matrice virale</term>
<term>Protéines proto-oncogènes c-akt</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Autophagie</term>
<term>Autophagosomes</term>
<term>Calcium</term>
<term>Transduction du signal</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Autophagosomes</term>
<term>Autophagy</term>
<term>Influenza A virus</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Autophagosomes</term>
<term>Influenza A virus</term>
<term>Mitochondria</term>
<term>Phosphatidylinositol 3-Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Autophagosomes</term>
<term>Calcium</term>
<term>Espèces réactives de l'oxygène</term>
<term>Mitochondries</term>
<term>Phosphatidylinositol 3-kinases</term>
<term>Protéine-5 associée à l'autophagie</term>
<term>Protéines adaptatrices de la transduction du signal</term>
<term>Protéines de la matrice virale</term>
<term>Protéines proto-oncogènes c-akt</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Autophagosomes</term>
<term>Mitochondries</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Autophagosomes</term>
<term>Mitochondria</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term>
<term>HEK293 Cells</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Protein Binding</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cellules A549</term>
<term>Cellules HEK293</term>
<term>Cellules HeLa</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Influenza A virus can evade host innate immune response that is involved in several viral proteins with complicated mechanisms. To date, how influenza A M2 protein modulates the host innate immunity remains unclear. Herein, we showed that M2 protein colocalized and interacted with MAVS (mitochondrial antiviral signaling protein) on mitochondria, and positively regulated MAVS-mediated innate immunity. Further studies revealed that M2 induced reactive oxygen species (ROS) production that was required for activation of macroautophagy/autophagy and enhancement of MAVS signaling pathway. Importantly, the proton channel activity of M2 protein was demonstrated to be essential for ROS production and antagonizing the autophagy pathway to control MAVS aggregation, thereby enhancing MAVS signal activity. In conclusion, our studies provided novel insights into mechanisms of M2 protein in modulating host antiviral immunity and uncovered a new mechanism into biology and pathogenicity of influenza A virus. <b>Abbreviations</b>
: AKT/PKB: AKT serine/threonine kinase; Apo: apocynin; ATG5: autophagy related 5; BAPTA-AM: 1,2-Bis(2-aminophenoxy) ethane-<i>N,N,N',N'</i>
-tetraacetic acid tetrakis; BECN1: beclin 1; CARD: caspase recruitment domain; CCCP: carbonyl cyanide m-chlorophenylhydrazone; CQ: chloroquine; DCF: dichlorodihyd-rofluorescein; DPI: diphenyleneiodonium; DDX58: DExD/H-box helicase 58; eGFP: enhanced green fluorescent protein; EGTA: ethylene glycol-bis(2-aminoethylether)-<i>N,N,N',N'</i>
-tetraacetic acid; ER: endoplasmic reticulum; hpi: hours post infection; IAV: influenza A virus; IFN: interferon; IP: immunoprecipitation; IRF3: interferon regulatory factor 3; ISRE: IFN-stimulated response elements; LIR: LC3-interacting region; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAVS: mitochondrial antiviral signaling protein; MMP: mitochondrial membrane potential; MOI, multiplicity of infection; mRFP: monomeric red fluorescent protein; MTOR: mechanistic target of rapamycin kinase; NC: negative control; NFKB/NF-κB: nuclear factor kappa B; PI3K: class I phosphoinositide 3-kinase; RLR: RIG-I-like-receptor; ROS: reactive oxygen species; SEV: sendai virus; TM: transmembrane; TMRM: tetramethylrhodamine methylester; VSV: vesicular stomatitis virus.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30741586</PMID>
<DateCompleted><Year>2020</Year>
<Month>06</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1554-8635</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<Issue>7</Issue>
<PubDate><Year>2019</Year>
<Month>07</Month>
</PubDate>
</JournalIssue>
<Title>Autophagy</Title>
<ISOAbbreviation>Autophagy</ISOAbbreviation>
</Journal>
<ArticleTitle>Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.</ArticleTitle>
<Pagination><MedlinePgn>1163-1181</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/15548627.2019.1580089</ELocationID>
<Abstract><AbstractText>Influenza A virus can evade host innate immune response that is involved in several viral proteins with complicated mechanisms. To date, how influenza A M2 protein modulates the host innate immunity remains unclear. Herein, we showed that M2 protein colocalized and interacted with MAVS (mitochondrial antiviral signaling protein) on mitochondria, and positively regulated MAVS-mediated innate immunity. Further studies revealed that M2 induced reactive oxygen species (ROS) production that was required for activation of macroautophagy/autophagy and enhancement of MAVS signaling pathway. Importantly, the proton channel activity of M2 protein was demonstrated to be essential for ROS production and antagonizing the autophagy pathway to control MAVS aggregation, thereby enhancing MAVS signal activity. In conclusion, our studies provided novel insights into mechanisms of M2 protein in modulating host antiviral immunity and uncovered a new mechanism into biology and pathogenicity of influenza A virus. <b>Abbreviations</b>
: AKT/PKB: AKT serine/threonine kinase; Apo: apocynin; ATG5: autophagy related 5; BAPTA-AM: 1,2-Bis(2-aminophenoxy) ethane-<i>N,N,N',N'</i>
-tetraacetic acid tetrakis; BECN1: beclin 1; CARD: caspase recruitment domain; CCCP: carbonyl cyanide m-chlorophenylhydrazone; CQ: chloroquine; DCF: dichlorodihyd-rofluorescein; DPI: diphenyleneiodonium; DDX58: DExD/H-box helicase 58; eGFP: enhanced green fluorescent protein; EGTA: ethylene glycol-bis(2-aminoethylether)-<i>N,N,N',N'</i>
-tetraacetic acid; ER: endoplasmic reticulum; hpi: hours post infection; IAV: influenza A virus; IFN: interferon; IP: immunoprecipitation; IRF3: interferon regulatory factor 3; ISRE: IFN-stimulated response elements; LIR: LC3-interacting region; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAVS: mitochondrial antiviral signaling protein; MMP: mitochondrial membrane potential; MOI, multiplicity of infection; mRFP: monomeric red fluorescent protein; MTOR: mechanistic target of rapamycin kinase; NC: negative control; NFKB/NF-κB: nuclear factor kappa B; PI3K: class I phosphoinositide 3-kinase; RLR: RIG-I-like-receptor; ROS: reactive oxygen species; SEV: sendai virus; TM: transmembrane; TMRM: tetramethylrhodamine methylester; VSV: vesicular stomatitis virus.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Ruifang</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Yinxing</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Xian</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ren</LastName>
<ForeName>Chenwei</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Jiachang</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Fangfang</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Xiaochen</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xiao</LastName>
<ForeName>Rong</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Lianzhong</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Huanchun</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jin</LastName>
<ForeName>Meilin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Wenjun</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>c Department of Diagnostic Medicine and Pathobiology , Kansas State University , Manhattan , KS , USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Hongbo</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>a State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine , Huazhong Agricultural University , Wuhan , China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory of Preventive Veterinary Medicine in Hubei Province , the Cooperative Innovation Center for Sustainable Pig Production , Wuhan , China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>02</Month>
<Day>20</Day>
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<name sortKey="Zhu, Yinxing" sort="Zhu, Yinxing" uniqKey="Zhu Y" first="Yinxing" last="Zhu">Yinxing Zhu</name>
<name sortKey="Zhu, Yinxing" sort="Zhu, Yinxing" uniqKey="Zhu Y" first="Yinxing" last="Zhu">Yinxing Zhu</name>
</country>
<country name="États-Unis"><region name="Kansas"><name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name>
</region>
</country>
</tree>
</affiliations>
</record>

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EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000318 | SxmlIndent | more

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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30741586
   |texte=   Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:30741586" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.

Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.

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